Regulation of inflammatory processes / Natural Cox-2 and 5-LOX inhibitor (with Perluxan™ 500 and Boswellia 30% AKBA)
Oxiflam™ is a natural formula designed to help inhibit inflammation. It contains a combination of super strenght herbal extracts that can bring an overall boost to global heath, detoxify the body and improve numerous psysiological functions. Oxiflam™ intervenes in the earliest stages of the cascade of events leading to tissue degradation and it can help maintain healthy joints against the destructive inflammatory pathways.
(Oxiflam™ can be used in combination with Hyalgen™ which is specifically formulated for supporting the cartilage structure.)
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Daily serving size: 3 capsules / Servings per container: 50
Caution: Pregnant or nursing mothers, children under 18 and those with a medical condition should consult a health care professional before using this product.
Inflammation! ... What you need to know
Inflammation is the body's natural response to injury, but it is also recognized as a major cause to many major human deseases. Chronic inflammation ends up affecting healthy cells and destroying the tissues it was designed to protect. Apparently unrelated disorders such as MS, Alzheimer's, arthritis, asthma, bowel desease or even certain cancers all have common inflammatory elements underlying the disease process.
Inflammation is also almost systematically involved in all joint diseases. It can be the initiating factor as it is the case with rheumatoid arthritis, or not, but it always plays a major role in triggering off joint pain and causing great loss of mobility.
The mechanisms behind inflammation can be classified in two major pathways, that of the COX enzymes and that of the lesser known 5-LOX enzymes. Traditional treatments, called NSAIDs inhibit the COX route but there are also 2 different classes of COX enzymes:
- The COX-2, responsible for the inflammation and pain, as in arthritis. But not only.
- The COX-1, responsible for maintenance and protection of the gastrointestinal tract.
Most NSAIDs block both the COX-1 and COX-2 and that is why they induce dangerous gastric side effects.
Perluxan™ (Selective Cox-2 inhibitor)
Perluxan is a standardized supercritical extract of hops with a high concentration in alpha acids. It is by far the most potent and the most selective natural COX-2 inhibitor known. The clinical results show that Perluxan™ is just as effective as the standard drugs Ibuprofen or Celebrex, but without the side effects.
POTENCY: After a 1000mg inake, more than half of the inflammatory COX-2 activity is inhibited, which translates into a strong reduction in joint pain and a significative lessening of inflammation.
SELECTIVITY: In clinical assessment Perluxan™ has shown to be 50 times more potent at inhibiting COX-2 than COX-1 which eliminates the risk of gastrointestinal irritation.
Perluxan® also possesses important antioxydant properties that help improve the general health condition and limit the oxidative stress.
There are new generation NSAIDs that selectively block only the COX-2 pathway and therefore aren't so harmful to the digestive tract, but they have been found to increase the rate of renal failures and heart attacks, and they still allow the production of leukotrienes through the 5-LOX inflammation pathway, which are just as devastating.
To summarize, a good inflammatory substance can be evaluated with two criterias:
- Efficacy : Potency in suppressing the COX-2 enzymes linked to inflammation
- Selectivity : Preservation of the COX-1 enzymes
But a dual action upon both inflammatory pathways, the 5-LOX leukotrienes as well as the COX-2 prostaglandines do seem to yield the best results today.
Boswellia Serrata (30% AKBA) - Non-redox 5-LOX inhibitor
For centuries the Ayurvedic medicine has utilized Boswellia for its anti-inflammatory properties derived from its content in boswellic acids that are natural, selective 5-lipoxygenase inhibitors. And one of them, the AKBA acid is the most active.
Oxiflam™ provides a higher concentration of AKBA, standardized to 30%, while other Boswellic acid fractions contain only 2% or 3%. This is why Oxiflam™ is a very effective 5-LOX inhibitor, an enzyme that plays a key rôle in the biosynthesis of pro-inflammatory leukotrienes.
Boswellla 30% AKBA has also shown to significantly inhibit matrix metalloproteinase (MMP-3), enzymes that break down cartilage, collagen and connective tissues.
Boswellia 30% AKBA promotes joint comfort and function within 7 days! - Full effect reached at 90 days with 50% mobility improvement.
When it comes to joint pain and joint health MSM is very helpful, even for severe cases. MSM is a bioavailable natural form of organic sulfur found in all living organisms. It is exceptionally well tolerated, it is rated as one of the least toxic substances in biology, close to water. Sulfur is necessary for making collagen, the primary constituent of cartilage and connective tissue.
Sulfur is the third most abundant mineral in your body, after calcium and phosphorous, and yet it is often called the forgotten mineral. It has been neglected because of the widespread assumption that a person's sulfur requirement was met with adequate protein intake, providing the amino acids methionine and cysteine, but disfunctions in methionine metabolism could induce sulfur deficiencies. Nevertheless, scientists have observed that the sulfur content of cartilage decreases with age, and that this decrease parallels degeneration in the joints. A study has clearly shown that arthritic joints have sulfur levels three times lower than healthy ones.
MSM supplementation significantly improves chronic pain for most people, without any side effects and MSM daily intake can be substantial, up to several grams. Aside from its anti-inflammatory action MSM can also stimulate the the immune system and improve the internal production of Glutathione, the body's major own antioxidant.
Oxiflam™ Bioactive Botanicals
Originating from Africa, this plant is traditionnally used for its benefits on the joints and rheumatic ailments. Several clinical trials have confirmed its effectiveness in improving mobility and in the treatment of low back pain as well as arthritis caused hip and knee pain. Its potency seems to be derived from a complex interraction of several substances contained in its root rather than solely within the harpagosides.
The health benefits of Curcuma are too numerous to list, but it is just one of the most useful substances for the prevention of all degenerative diseases. It is also an anti-oxydant and a powerful anti-inflammatory compound particularly useful for joint health. It slows down the pro-inflammatory leukotrienes synthesis and it stimulates fibrin destruction, fibrin deposition within the joints being a prominent feature of arthritis.
Stinging Nettle Leaf
Nettle leaf extract contains active compounds that reduce TNF-alpha and other inflammatory cytokines which play a major rôle in cartilage destruction. The inhibition happens at the genetic transcription, that is to say in the earliest stages of the pro-inflammatory process. It is also very useful for autoimmune joint problems. It acts upon both the cyclo-oxygenase (Cox-2) level and the lipo-oxygenase, (5-Lox) level.
Research has demonstrated the immunological and anti-inflammatory effects of Ginseng. It contains several chemical compounds called Ginsenosides that possess numerous biological activities. Studies conclude that their combination could selectively inhibit the expression of inflammatory genes leading to decreases in the production of cytokines and mediators of inflammation.
Maritime Pine Bark Extract
Studies show that Pine Bark extract inhibits the generation of COX-2 and 5-LOX, two enzymes associated with a host of inflammatory conditions. It does not have an effect on generation of the COX-1 enzyme, meaning that it does not trigger the typical NSAID side effects. Pine Bark extract blocks the COX-2 enzyme production during inflammation only, but it does not block the COX-2 enzymes where it has important physiologic functions in other organs such as the kidneys. Clinical trials also showed pain relief and a reduced need for pain medication in arthritis patients after taking Pine Bark extract.
Cat’s claw is a woody vine native to South and Central America. It has strong antioxidant and anti-inflammatory effects. It inhibits the production of TNF-alpha, an inflammatory messenger triggering both acute and chronic inflammation. It also inhibits the activation of NF-kappa beta, an inflammatory protein that is associated with cancer and other deadly diseases. Cat’s claw raises IGF-1 levels, a cartilage-protective insulin-like hormone. By inhibiting inflammatory agents that degrade cartilage while activating IGF-1, Cat’s claw can help preserve healthy joints.
It is a group of digestive enzymes that is found mostly in the stems of pineapples but it is present in all parts of the plant and fruit. It is very beneficial for people with arthritis and it works in inhibiting the Cox-2 pro-inflammatory pathway as well as the fibrin synthesis. Bromelain has demonstrated that it can be absorbed in human digestive track intact and retaining its biological activity (1)
A powerful herb traditionally used in Ayurveda and Chinese Medicine. It is a very potent global health enhancer and several studies show that it inhibits cancer cell growth and promotes cancer cell death. It is also one of the most effective anti-inflammatories. It naturally activate PPAR gamma, thereby inhibiting NF-kappa-beta, deactivating T-cell proliferation and reducing pro‐inflammatory cytokines. Andrographis can efficiently block T-cell activation in cases of detrimental T-cell responses.
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- Andrographolide inhibits osteopontin expression and breast tumor growth through down regulation of PI3 kinase/Akt signaling pathway. Curr Mol Med.2012 Sep;12(8):952-66. Bromelain
- (1)Intestinal absorption of undegraded proteins in men: presence of bromelain in plasma after oral intake. Castell JV, Friedrich G, Kuhn CS, Poppe GE Am J Physiol. 1997 Jul; 273(1 Pt 1):G139-46.
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
|Subtitle||Regulation of inflammatory processes / Natural Cox-2 and 5-LOX inhibitor (with Perluxan™ 500 and Boswellia 30% AKBA)|